Assessment of immunohistochemical expression of minichromosome maintenance protein (MCM-5) in oral squamous cell carcinoma and its clinicopathological correlation


Original Article

Author Details : Pragati Uttam Barge*, Jayanti Govind Humbe, Mandakini Subhash Mandale, Jyoti Dilip Bhavthankar, Preshit Laxman Kadam, Preshit Laxman Kadam

Volume : 14, Issue : 1, Year : 2024

Article Page : 41-47

https://doi.org/10.18231/j.adr.2024.008



Suggest article by email

Get Permission

Abstract

Introduction: Oral and oropharyngeal carcinomas are common cancers in the world. Therefore, for early diagnosis, prognosis, disease progression monitoring and treatment response, cancer biomarkers are identified as signature molecules.
Aim and Objectives: To evaluate and compare the immunohistochemical expression of MCM-5 in oral squamous cell carcinoma (OSCC) between clinical stages and its histopathological grades.
Descriptive cross sectional – in vitro study.
This study used immunohistochemistry to examine expression of MCM5 protein in 40 specimens of OSCC and evaluated for localization and staining intensity of MCM-5.
Results : Among 40 cases 39 showed positivity of MCM-5 regarding localization, with highly significant (p < 0> Conclusion: MCM-5 can be promising diagnostic and prognostic markers, as well as potential targets for anticancer therapy.


Keywords: Therapy. Keyword: MCM-5, Oral squamous cell carcinoma, Prognosis, Progression


How to cite : Barge P U, Humbe J G, Mandale M S, Bhavthankar J D, Kadam P L, Kadam P L, Assessment of immunohistochemical expression of minichromosome maintenance protein (MCM-5) in oral squamous cell carcinoma and its clinicopathological correlation. Arch Dent Res 2024;14(1):41-47


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International, which allows others to remix, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







Article History

Received : 10-04-2024

Accepted : 14-06-2024


View Article

PDF File   Full Text Article


Copyright permission

Get article permission for commercial use

Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/10.18231/j.adr.2024.008


Article Metrics






Article Access statistics

Viewed: 275

PDF Downloaded: 91



Medical Abbreviation List